Double-stranded RNA (dsRNA), which is a type of RNA with a complementary strand, similar to DNA found in cells. dsRNA makes up the genome of some viruses (double-stranded RNA viruses). Double-stranded RNAs such as viral RNA or siRNA are able to promote RNA interference in eukaryotic cells and elicit an interferon response in vertebrates. This standard is formed in vitro by T7 RNA polymerase in vitro by annealing after transcription using a DNA sequence with a T7 promoter as a template and four NTPs (ATP, GTP, CTP, N1-me-pseudo-UTP) as substrates.
